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ADRB3 ADRB3 GNAI3 GNAI3 GNAI2 GNAI2 GNAI1 GNAI1 ADRB1 ADRB1 ADRB2 ADRB2 GNAS-2 GNAS-2 GNAL GNAL UCP2 UCP2 PRDM16 PRDM16 CIDEA CIDEA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa)    
Predicted Functional Partners:
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
    
 0.922
GNAI2
G protein subunit alpha i2.
    
 0.920
GNAI1
Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.
    
 0.917
ADRB1
Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
   
 
0.915
ADRB2
Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity).
   
 
0.909
GNAS-2
Guanine nucleotide-binding protein G(s) subunit alpha.
    
  0.906
GNAL
G protein subunit alpha L.
    
 0.774
UCP2
Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).
   
  
 0.711
PRDM16
PR/SET domain 16.
   
  
 0.693
CIDEA
CIDE-N domain-containing protein.
      
 0.675
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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