STRINGSTRING
CSTB CSTB CTSB CTSB CTSV CTSV LOC100515765 LOC100515765 CLUL1 CLUL1 CTSS CTSS CTSL CTSL TTF1 TTF1 ISYNA1 ISYNA1 S100A12 S100A12 CTSC CTSC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CSTBCystatin-B; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (98 aa)    
Predicted Functional Partners:
CTSB
Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).
   
 
 0.614
CTSV
Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.
    
 
 0.539
LOC100515765
Cystatin domain-containing protein.
    
 
 0.490
CLUL1
Clusterin; Belongs to the clusterin family.
      
 0.468
CTSS
Cathepsin S; Belongs to the peptidase C1 family.
   
 
 0.464
CTSL
Cathepsin L1 isoform 1 preproprotein; Belongs to the peptidase C1 family.
    
 
 0.462
TTF1
Uncharacterized protein.
      
 0.457
ISYNA1
Inositol-3-phosphate synthase 1.
      
 0.440
S100A12
Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]
   
 
  0.438
CTSC
Cathepsin C; Belongs to the peptidase C1 family.
   
 
 0.429
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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