STRINGSTRING
PRXL2B PRXL2B HPGDS HPGDS PTGES PTGES PTGS2 PTGS2 PTGS1 PTGS1 PTGES2 PTGES2 PTGDS PTGDS TBXAS1 TBXAS1 PTGIS PTGIS CBR3 CBR3 LOC100622246 LOC100622246
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PRXL2BProstamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). (202 aa)    
Predicted Functional Partners:
HPGDS
Hematopoietic prostaglandin D synthase.
     
 0.935
PTGES
Microsomal prostaglandin E synthase-1.
     
 0.920
PTGS2
Prostaglandin G/H synthase 2.
     
 0.916
PTGS1
Prostaglandin G/H synthase 1 isoform 1.
     
 0.911
PTGES2
Prostaglandin E synthase 2.
     
 0.908
PTGDS
Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...]
     
 0.908
TBXAS1
Thromboxane-A synthase; Belongs to the cytochrome P450 family.
     
 0.902
PTGIS
Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family.
     
 0.901
CBR3
Carbonyl reductase NADPH 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.901
LOC100622246
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.901
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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