STRINGSTRING
BEST1 BEST1 RPE65 RPE65 MERTK MERTK RLBP1 RLBP1 MITF MITF RD3 RD3 RHO RHO TYR TYR CNGB3 CNGB3 PRCD PRCD CRX CRX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BEST1Bestrophin-1; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity); Belongs to the bestrophin family. (579 aa)    
Predicted Functional Partners:
RPE65
Retinoid isomerohydrolase RPE65.
      
 0.903
MERTK
MER proto-oncogene, tyrosine kinase.
      
 0.786
RLBP1
Retinaldehyde binding protein 1.
   
  
 0.759
MITF
Microphthalmia-associated transcription factor isoform 1.
   
  
 0.734
RD3
Retinal degeneration 3, GUCY2D regulator.
      
 0.662
RHO
Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
   
  
 0.638
TYR
Tyrosinase.
      
 0.625
CNGB3
Cyclic nucleotide gated channel subunit beta 3.
      
 0.615
PRCD
Photoreceptor disc component.
      
 0.615
CRX
Cone-rod homeobox.
      
 0.612
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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