PTPRC protein (Homo sapiens) - STRING network view

STRING 9.05

PTPRC protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	PTPRC	protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN (1304 aa)
		(Homo sapiens)
Predicted Functional Partners:
	LCK	lymphocyte-specific protein tyrosine kinase; Tyrosine kinase that plays an essential role for t [...] (509 aa)	•	•	•	•	0.999
	CD22	CD22 molecule; Mediates B-cell B-cell interactions. May be involved in the localization of B-ce [...] (847 aa)	•	•	•	•	0.999
	CD4	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regul [...] (458 aa)		•	•	•	0.994
	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain [...] (862 aa)		•	•	•	0.993
	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)	•	•	•	•	0.992

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: medium (67%)

Permalink