node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBS | SPTLC1 | ENSBTAP00000063539 | ENSBTAP00000002872 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.852 |
CBS | SPTLC2 | ENSBTAP00000063539 | ENSBTAP00000027289 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine palmitoyltransferase long chain base subunit 2. | 0.846 |
CBS | SPTLC3 | ENSBTAP00000063539 | ENSBTAP00000018946 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine palmitoyltransferase long chain base subunit 3. | 0.848 |
ISM1 | KDSR | ENSBTAP00000022843 | ENSBTAP00000010155 | Isthmin 1. | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.745 |
ISM1 | ORMDL1 | ENSBTAP00000022843 | ENSBTAP00000016673 | Isthmin 1. | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | 0.591 |
ISM1 | ORMDL2 | ENSBTAP00000022843 | ENSBTAP00000027540 | Isthmin 1. | ORM1-like protein 2; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | 0.591 |
ISM1 | ORMDL3 | ENSBTAP00000022843 | ENSBTAP00000018402 | Isthmin 1. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.591 |
ISM1 | SPTLC1 | ENSBTAP00000022843 | ENSBTAP00000002872 | Isthmin 1. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.927 |
ISM1 | SPTSSA | ENSBTAP00000022843 | ENSBTAP00000018578 | Isthmin 1. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.534 |
KDSR | ISM1 | ENSBTAP00000010155 | ENSBTAP00000022843 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Isthmin 1. | 0.745 |
KDSR | SPTLC1 | ENSBTAP00000010155 | ENSBTAP00000002872 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.996 |
KDSR | SPTLC2 | ENSBTAP00000010155 | ENSBTAP00000027289 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase long chain base subunit 2. | 0.994 |
KDSR | SPTLC3 | ENSBTAP00000010155 | ENSBTAP00000018946 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase long chain base subunit 3. | 0.993 |
KDSR | SPTSSA | ENSBTAP00000010155 | ENSBTAP00000018578 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI). | 0.663 |
ORMDL1 | ISM1 | ENSBTAP00000016673 | ENSBTAP00000022843 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Isthmin 1. | 0.591 |
ORMDL1 | ORMDL2 | ENSBTAP00000016673 | ENSBTAP00000027540 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | ORM1-like protein 2; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | 0.567 |
ORMDL1 | ORMDL3 | ENSBTAP00000016673 | ENSBTAP00000018402 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). | 0.550 |
ORMDL1 | SPTLC1 | ENSBTAP00000016673 | ENSBTAP00000002872 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...] | 0.958 |
ORMDL1 | SPTLC2 | ENSBTAP00000016673 | ENSBTAP00000027289 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Serine palmitoyltransferase long chain base subunit 2. | 0.919 |
ORMDL1 | SPTLC3 | ENSBTAP00000016673 | ENSBTAP00000018946 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. | Serine palmitoyltransferase long chain base subunit 3. | 0.905 |