STRINGSTRING
WDR48 WDR48 USP1 USP1 USP12 USP12 WDR20 WDR20 USP46 USP46 FANCI FANCI RAD51AP1 RAD51AP1 FANCL FANCL FANCD2 FANCD2 ATAD5 ATAD5 RPS27A RPS27A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
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[Homology]
Score
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (677 aa)    
Predicted Functional Partners:
USP1
Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA- mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Belongs to the peptidase C19 family.
   
 0.999
USP12
Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily.
   
 0.996
WDR20
WD repeat domain 20.
    
 0.993
USP46
Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family.
   
 
 0.989
FANCI
FA complementation group I.
    
 0.987
RAD51AP1
RAD51 associated protein 1.
    
 
 0.973
FANCL
Fanconi anemia, complementation group L.
   
 
 0.954
FANCD2
FA complementation group D2.
    
 0.925
ATAD5
ATPase family AAA domain containing 5.
   
 
 0.895
RPS27A
Ubiquitin-40S ribosomal protein S27a.
    
 0.861
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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