STRINGSTRING
NUDC NUDC PLK1 PLK1 PAFAH1B1 PAFAH1B1 CLASP2 CLASP2 SGO1 SGO1 NDEL1 NDEL1 BUB1 BUB1 INCENP INCENP CLIP1 CLIP1 NDE1 NDE1 SGO2 SGO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
NUDCNuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity); Belongs to the nudC family. (332 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...]
   
 0.969
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]
   
 0.939
CLASP2
Cytoplasmic linker associated protein 2.
     
 0.921
SGO1
Shugoshin 1.
    
 0.910
NDEL1
NudE neurodevelopment protein 1 like 1.
     
 0.902
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
     
 0.882
INCENP
Inner centromere protein.
     
 0.880
CLIP1
CAP-Gly domain containing linker protein 1.
     
 0.863
NDE1
NudE neurodevelopment protein 1.
     
 0.860
SGO2
Shugoshin 2.
     
 0.855
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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