node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG1 | BAG2 | ENSBTAP00000023720 | ENSBTAP00000007039 | BCL2 associated athanogene 1. | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | 0.985 |
BAG1 | BAG3 | ENSBTAP00000023720 | ENSBTAP00000018131 | BCL2 associated athanogene 1. | BCL2 associated athanogene 3. | 0.899 |
BAG1 | BAG4 | ENSBTAP00000023720 | ENSBTAP00000017468 | BCL2 associated athanogene 1. | BCL2 associated athanogene 4. | 0.821 |
BAG1 | HSPA1A | ENSBTAP00000023720 | ENSBTAP00000017500 | BCL2 associated athanogene 1. | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.987 |
BAG1 | HSPA1L | ENSBTAP00000023720 | ENSBTAP00000035635 | BCL2 associated athanogene 1. | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.783 |
BAG1 | HSPA4L | ENSBTAP00000023720 | ENSBTAP00000064377 | BCL2 associated athanogene 1. | Heat shock protein family A (Hsp70) member 4 like. | 0.954 |
BAG1 | HSPA6 | ENSBTAP00000023720 | ENSBTAP00000051168 | BCL2 associated athanogene 1. | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. | 0.757 |
BAG1 | HSPA8 | ENSBTAP00000023720 | ENSBTAP00000058201 | BCL2 associated athanogene 1. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.999 |
BAG1 | HSPBP1 | ENSBTAP00000023720 | ENSBTAP00000068472 | BCL2 associated athanogene 1. | HSPA (Heat shock 70kDa) binding protein, cytoplasmic cochaperone 1. | 0.966 |
BAG1 | HSPH1 | ENSBTAP00000023720 | ENSBTAP00000006600 | BCL2 associated athanogene 1. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.949 |
BAG2 | BAG1 | ENSBTAP00000007039 | ENSBTAP00000023720 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | BCL2 associated athanogene 1. | 0.985 |
BAG2 | BAG3 | ENSBTAP00000007039 | ENSBTAP00000018131 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | BCL2 associated athanogene 3. | 0.871 |
BAG2 | BAG4 | ENSBTAP00000007039 | ENSBTAP00000017468 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | BCL2 associated athanogene 4. | 0.790 |
BAG2 | HSPA1A | ENSBTAP00000007039 | ENSBTAP00000017500 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.977 |
BAG2 | HSPA1L | ENSBTAP00000007039 | ENSBTAP00000035635 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.780 |
BAG2 | HSPA4L | ENSBTAP00000007039 | ENSBTAP00000064377 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock protein family A (Hsp70) member 4 like. | 0.947 |
BAG2 | HSPA6 | ENSBTAP00000007039 | ENSBTAP00000051168 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. | 0.783 |
BAG2 | HSPA8 | ENSBTAP00000007039 | ENSBTAP00000058201 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.985 |
BAG2 | HSPBP1 | ENSBTAP00000007039 | ENSBTAP00000068472 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | HSPA (Heat shock 70kDa) binding protein, cytoplasmic cochaperone 1. | 0.960 |
BAG2 | HSPH1 | ENSBTAP00000007039 | ENSBTAP00000006600 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.955 |