STRINGSTRING
ATP2A1 ATP2A1 PLN PLN TNNI2 TNNI2 TNNC2 TNNC2 SLN SLN HRC HRC ATP2A2 ATP2A2 RORA RORA ATP2A3 ATP2A3 KAT5 KAT5 RYR1 RYR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATP2A1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. (993 aa)    
Predicted Functional Partners:
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Belongs to the phospholamban family.
   
 0.981
TNNI2
Troponin I2, fast skeletal type.
   
 
 0.954
TNNC2
Troponin C2, fast skeletal type.
   
 
 0.952
SLN
Uncharacterized protein.
   
 
 0.952
HRC
Histidine rich calcium binding protein.
   
 0.928
ATP2A2
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
  
  
0.909
RORA
RAR related orphan receptor A.
     
 0.906
ATP2A3
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
  
 
0.904
KAT5
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
    
 0.902
RYR1
Ryanodine receptor 1.
   
 
 0.893
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (18%) [HD]