node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | MYH2 | ENSBTAP00000006532 | ENSBTAP00000012797 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | 0.737 |
ACTA1 | MYL1 | ENSBTAP00000006532 | ENSBTAP00000049636 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.932 |
ACTA1 | MYL2 | ENSBTAP00000006532 | ENSBTAP00000066211 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.631 |
ACTA1 | MYL6B | ENSBTAP00000006532 | ENSBTAP00000041719 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin, light chain 6B, alkali, smooth muscle and non-muscle. | 0.482 |
ACTA1 | MYLPF | ENSBTAP00000006532 | ENSBTAP00000065724 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.761 |
ACTA1 | MYOD1 | ENSBTAP00000006532 | ENSBTAP00000002868 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). | 0.649 |
ACTA1 | MYOG | ENSBTAP00000006532 | ENSBTAP00000007923 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] | 0.726 |
ACTA1 | TNNC2 | ENSBTAP00000006532 | ENSBTAP00000055007 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin C2, fast skeletal type. | 0.716 |
ACTA1 | TNNI2 | ENSBTAP00000006532 | ENSBTAP00000014452 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin I2, fast skeletal type. | 0.750 |
ACTA1 | TNNT1 | ENSBTAP00000006532 | ENSBTAP00000073026 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.859 |
MYH2 | ACTA1 | ENSBTAP00000012797 | ENSBTAP00000006532 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.737 |
MYH2 | MYL1 | ENSBTAP00000012797 | ENSBTAP00000049636 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.791 |
MYH2 | MYL2 | ENSBTAP00000012797 | ENSBTAP00000066211 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.765 |
MYH2 | MYL6B | ENSBTAP00000012797 | ENSBTAP00000041719 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myosin, light chain 6B, alkali, smooth muscle and non-muscle. | 0.731 |
MYH2 | MYLPF | ENSBTAP00000012797 | ENSBTAP00000065724 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.792 |
MYH2 | MYOD1 | ENSBTAP00000012797 | ENSBTAP00000002868 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). | 0.766 |
MYH2 | MYOG | ENSBTAP00000012797 | ENSBTAP00000007923 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] | 0.770 |
MYH2 | TNNC2 | ENSBTAP00000012797 | ENSBTAP00000055007 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Troponin C2, fast skeletal type. | 0.873 |
MYH2 | TNNI2 | ENSBTAP00000012797 | ENSBTAP00000014452 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Troponin I2, fast skeletal type. | 0.759 |
MYH2 | TNNT1 | ENSBTAP00000012797 | ENSBTAP00000073026 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.730 |