STRINGSTRING
IAPP IAPP CALCR CALCR CALCRL CALCRL ADM ADM RAMP3 RAMP3 RAMP1 RAMP1 CALCB CALCB RAMP2 RAMP2 IDE IDE CALCA CALCA CALCB-2 CALCB-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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IAPPIslet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family. (91 aa)    
Predicted Functional Partners:
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.996
CALCRL
Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
    
 0.988
ADM
Proadrenomedullin N-20 terminal peptide; Hypotensive peptide. May function as a hormone in circulation control (By similarity); Belongs to the adrenomedullin family.
     
 0.980
RAMP3
Receptor activity modifying protein 3.
    
 0.979
RAMP1
Receptor activity modifying protein 1.
    
 0.970
CALCB
Calcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones; Belongs to the calcitonin family.
     
 0.965
RAMP2
Receptor activity modifying protein 2.
    
 0.961
IDE
Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling (By similarity). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation an [...]
    
 
 0.948
CALCA
Calcitonin-related polypeptide 3.
     
 0.947
CALCB-2
Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.
     
 0.931
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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