STRINGSTRING
ANGPTL1 ANGPTL1 ANGPTL8 ANGPTL8 TIE1 TIE1 IGDCC4 IGDCC4 TEK TEK FAM149A FAM149A PIP4K2A PIP4K2A ATP1A4 ATP1A4 INPP1 INPP1 ISM1 ISM1 FMO1 FMO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANGPTL1Angiopoietin-related protein 1. (491 aa)    
Predicted Functional Partners:
ANGPTL8
Angiopoietin like 8.
    
 
 0.770
TIE1
Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
   
 
 0.591
IGDCC4
Immunoglobulin superfamily DCC subclass member 4.
      
 0.573
TEK
Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angi [...]
   
 
 0.571
FAM149A
Family with sequence similarity 149 member A.
      
 0.554
PIP4K2A
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.
   
  
 0.540
ATP1A4
Sodium/potassium-transporting ATPase subunit alpha.
      
 0.522
INPP1
Inositol polyphosphate 1-phosphatase; Belongs to the inositol monophosphatase superfamily.
      
 0.522
ISM1
Isthmin 1.
      
 0.509
FMO1
Flavin-containing monooxygenase.
      
 0.483
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.