node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNIH4 | TMED1 | ENSBTAP00000025936 | ENSBTAP00000014563 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. | 0.697 |
CNIH4 | TMED10 | ENSBTAP00000025936 | ENSBTAP00000007481 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] | 0.679 |
CNIH4 | TMED9 | ENSBTAP00000025936 | ENSBTAP00000001830 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. | Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of t [...] | 0.644 |
DOK2 | ENDOD1 | ENSBTAP00000004337 | ENSBTAP00000034425 | Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | Endonuclease domain containing 1. | 0.468 |
DOK2 | SPPL3 | ENSBTAP00000004337 | ENSBTAP00000053963 | Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | Signal peptide peptidase like 3. | 0.585 |
DOK2 | TMED1 | ENSBTAP00000004337 | ENSBTAP00000014563 | Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. | 0.700 |
ENDOD1 | DOK2 | ENSBTAP00000034425 | ENSBTAP00000004337 | Endonuclease domain containing 1. | Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). | 0.468 |
ENDOD1 | FAM8A1 | ENSBTAP00000034425 | ENSBTAP00000022755 | Endonuclease domain containing 1. | Family with sequence similarity 8, member A1. | 0.692 |
ENDOD1 | RNF26 | ENSBTAP00000034425 | ENSBTAP00000044801 | Endonuclease domain containing 1. | Ring finger protein 26. | 0.834 |
ENDOD1 | TMED1 | ENSBTAP00000034425 | ENSBTAP00000014563 | Endonuclease domain containing 1. | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. | 0.837 |
ENDOD1 | TMEM33 | ENSBTAP00000034425 | ENSBTAP00000065097 | Endonuclease domain containing 1. | Transmembrane protein 33. | 0.878 |
ENDOD1 | TMEM43 | ENSBTAP00000034425 | ENSBTAP00000067254 | Endonuclease domain containing 1. | Uncharacterized protein. | 0.876 |
FAM8A1 | ENDOD1 | ENSBTAP00000022755 | ENSBTAP00000034425 | Family with sequence similarity 8, member A1. | Endonuclease domain containing 1. | 0.692 |
FAM8A1 | RNF26 | ENSBTAP00000022755 | ENSBTAP00000044801 | Family with sequence similarity 8, member A1. | Ring finger protein 26. | 0.527 |
FAM8A1 | TMED1 | ENSBTAP00000022755 | ENSBTAP00000014563 | Family with sequence similarity 8, member A1. | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. | 0.728 |
FAM8A1 | TMEM33 | ENSBTAP00000022755 | ENSBTAP00000065097 | Family with sequence similarity 8, member A1. | Transmembrane protein 33. | 0.668 |
FAM8A1 | TMEM43 | ENSBTAP00000022755 | ENSBTAP00000067254 | Family with sequence similarity 8, member A1. | Uncharacterized protein. | 0.549 |
RNF26 | ENDOD1 | ENSBTAP00000044801 | ENSBTAP00000034425 | Ring finger protein 26. | Endonuclease domain containing 1. | 0.834 |
RNF26 | FAM8A1 | ENSBTAP00000044801 | ENSBTAP00000022755 | Ring finger protein 26. | Family with sequence similarity 8, member A1. | 0.527 |
RNF26 | TMED1 | ENSBTAP00000044801 | ENSBTAP00000014563 | Ring finger protein 26. | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. | 0.713 |