node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGEF1 | ARL1 | ENSBTAP00000019553 | ENSBTAP00000015767 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.811 |
ARFIP2 | ARL1 | ENSBTAP00000063547 | ENSBTAP00000015767 | Arfaptin-2; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.951 |
ARL1 | ARFGEF1 | ENSBTAP00000015767 | ENSBTAP00000019553 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] | 0.811 |
ARL1 | ARFIP2 | ENSBTAP00000015767 | ENSBTAP00000063547 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Arfaptin-2; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. | 0.951 |
ARL1 | CCDC185 | ENSBTAP00000015767 | ENSBTAP00000008811 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Coiled-coil domain containing 185. | 0.900 |
ARL1 | CIAO1 | ENSBTAP00000015767 | ENSBTAP00000020797 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | 0.829 |
ARL1 | COG6 | ENSBTAP00000015767 | ENSBTAP00000022131 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.808 |
ARL1 | ENSBTAP00000070668 | ENSBTAP00000015767 | ENSBTAP00000070668 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Uncharacterized protein. | 0.765 |
ARL1 | GBF1 | ENSBTAP00000015767 | ENSBTAP00000053253 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Golgi brefeldin A resistant guanine nucleotide exchange factor 1. | 0.843 |
ARL1 | RAB6A | ENSBTAP00000015767 | ENSBTAP00000000027 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Uncharacterized protein. | 0.845 |
ARL1 | RAB6B | ENSBTAP00000015767 | ENSBTAP00000001199 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). | 0.824 |
ARL1 | STX16-NPEPL1 | ENSBTAP00000015767 | ENSBTAP00000005055 | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. | 0.771 |
CCDC185 | ARL1 | ENSBTAP00000008811 | ENSBTAP00000015767 | Coiled-coil domain containing 185. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.900 |
CIAO1 | ARL1 | ENSBTAP00000020797 | ENSBTAP00000015767 | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.829 |
CIAO1 | GBF1 | ENSBTAP00000020797 | ENSBTAP00000053253 | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] | Golgi brefeldin A resistant guanine nucleotide exchange factor 1. | 0.899 |
COG6 | ARL1 | ENSBTAP00000022131 | ENSBTAP00000015767 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.808 |
COG6 | RAB6A | ENSBTAP00000022131 | ENSBTAP00000000027 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Uncharacterized protein. | 0.810 |
COG6 | RAB6B | ENSBTAP00000022131 | ENSBTAP00000001199 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). | 0.714 |
COG6 | STX16-NPEPL1 | ENSBTAP00000022131 | ENSBTAP00000005055 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. | 0.922 |
ENSBTAP00000070668 | ARL1 | ENSBTAP00000070668 | ENSBTAP00000015767 | Uncharacterized protein. | ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). | 0.765 |