STRINGSTRING
AASS AASS ALDH7A1 ALDH7A1 PHYKPL PHYKPL SRM SRM BTD BTD SOD2 SOD2 DMAC2 DMAC2 GTF2F1 GTF2F1 AASDH AASDH ODC1 ODC1 AZIN1 AZIN1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AASSAlpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). (926 aa)    
Predicted Functional Partners:
ALDH7A1
Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity); Belongs to the aldehyde dehydrogenase family.
  
 
 0.957
PHYKPL
5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.934
SRM
Spermidine synthase; Belongs to the spermidine/spermine synthase family.
    
 0.923
BTD
Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
  
 
 0.819
SOD2
Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
    
 0.778
DMAC2
Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
      
 0.704
GTF2F1
General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity); Belongs to the TFIIF alpha subunit family.
 
      0.693
AASDH
Aminoadipate-semialdehyde dehydrogenase.
  
 
 0.692
ODC1
Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
 
 0.678
AZIN1
Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
  
 
 0.678
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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