B2M protein (Bos taurus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B2M

Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)

Predicted Functional Partners:

BOLA-2

0.995

CALR

0.976

BoLA

0.973

BOLA-NC1

0.971

CD1D

0.970

JSP.1

0.967

BOLA

0.964

TAPBP

0.956

LOC509006

0.956

CD1B

0.954

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	BOLA	ENSBTAP00000016359	ENSBTAP00000016194	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.964
B2M	BOLA-2	ENSBTAP00000016359	ENSBTAP00000035745	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system.	0.995
B2M	BOLA-NC1	ENSBTAP00000016359	ENSBTAP00000021451	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.971
B2M	BoLA	ENSBTAP00000016359	ENSBTAP00000059934	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.973
B2M	CALR	ENSBTAP00000016359	ENSBTAP00000020111	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.	0.976
B2M	CD1B	ENSBTAP00000016359	ENSBTAP00000066316	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1b3.	0.954
B2M	CD1D	ENSBTAP00000016359	ENSBTAP00000068947	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.970
B2M	JSP.1	ENSBTAP00000016359	ENSBTAP00000070120	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.967
B2M	LOC509006	ENSBTAP00000016359	ENSBTAP00000072816	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.956
B2M	TAPBP	ENSBTAP00000016359	ENSBTAP00000022386	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	TAP binding protein (Tapasin).	0.956
BOLA	B2M	ENSBTAP00000016194	ENSBTAP00000016359	Ig-like domain-containing protein; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.964
BOLA	BOLA-2	ENSBTAP00000016194	ENSBTAP00000035745	Ig-like domain-containing protein; Belongs to the MHC class I family.	BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system.	0.693
BOLA	BOLA-NC1	ENSBTAP00000016194	ENSBTAP00000021451	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.690
BOLA	BoLA	ENSBTAP00000016194	ENSBTAP00000059934	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.686
BOLA	CALR	ENSBTAP00000016194	ENSBTAP00000020111	Ig-like domain-containing protein; Belongs to the MHC class I family.	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.	0.931
BOLA	JSP.1	ENSBTAP00000016194	ENSBTAP00000070120	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.671
BOLA	LOC509006	ENSBTAP00000016194	ENSBTAP00000072816	Ig-like domain-containing protein; Belongs to the MHC class I family.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.650
BOLA	TAPBP	ENSBTAP00000016194	ENSBTAP00000022386	Ig-like domain-containing protein; Belongs to the MHC class I family.	TAP binding protein (Tapasin).	0.944
BOLA-2	B2M	ENSBTAP00000035745	ENSBTAP00000016359	BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.995
BOLA-2	BOLA	ENSBTAP00000035745	ENSBTAP00000016194	BOLA class I histocompatibility antigen, alpha chain BL3-7; Involved in the presentation of foreign antigens to the immune system.	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.693

page 1 of 4

Server load: low (14%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2023

Credits

Access

Info

About