node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUSP16 | EDA | ENSBTAP00000000929 | ENSBTAP00000016649 | Dual specificity phosphatase 16. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | 0.420 |
DUSP16 | MAPK10 | ENSBTAP00000000929 | ENSBTAP00000026712 | Dual specificity phosphatase 16. | Mitogen-activated protein kinase. | 0.976 |
DUSP16 | MAPK8 | ENSBTAP00000000929 | ENSBTAP00000073182 | Dual specificity phosphatase 16. | Mitogen-activated protein kinase. | 0.774 |
DUSP16 | MAPK9 | ENSBTAP00000000929 | ENSBTAP00000061184 | Dual specificity phosphatase 16. | Mitogen-activated protein kinase. | 0.602 |
EDA | DUSP16 | ENSBTAP00000016649 | ENSBTAP00000000929 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Dual specificity phosphatase 16. | 0.420 |
EDA | EDA2R | ENSBTAP00000016649 | ENSBTAP00000054379 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Ectodysplasin A2 receptor. | 0.934 |
EDA | EDAR | ENSBTAP00000016649 | ENSBTAP00000026148 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Ectodysplasin A receptor. | 0.937 |
EDA | EDARADD | ENSBTAP00000016649 | ENSBTAP00000053309 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | EDAR associated death domain. | 0.618 |
EDA | MAP3K20 | ENSBTAP00000016649 | ENSBTAP00000058064 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Uncharacterized protein. | 0.587 |
EDA | MAP3K7 | ENSBTAP00000016649 | ENSBTAP00000058895 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.587 |
EDA | MAPK10 | ENSBTAP00000016649 | ENSBTAP00000026712 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Mitogen-activated protein kinase. | 0.570 |
EDA | MAPK8 | ENSBTAP00000016649 | ENSBTAP00000073182 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Mitogen-activated protein kinase. | 0.570 |
EDA | MAPK9 | ENSBTAP00000016649 | ENSBTAP00000061184 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | Mitogen-activated protein kinase. | 0.570 |
EDA | TBX1 | ENSBTAP00000016649 | ENSBTAP00000063978 | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | T-box transcription factor 1. | 0.437 |
EDA2R | EDA | ENSBTAP00000054379 | ENSBTAP00000016649 | Ectodysplasin A2 receptor. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | 0.934 |
EDAR | EDA | ENSBTAP00000026148 | ENSBTAP00000016649 | Ectodysplasin A receptor. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | 0.937 |
EDAR | EDARADD | ENSBTAP00000026148 | ENSBTAP00000053309 | Ectodysplasin A receptor. | EDAR associated death domain. | 0.989 |
EDARADD | EDA | ENSBTAP00000053309 | ENSBTAP00000016649 | EDAR associated death domain. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | 0.618 |
EDARADD | EDAR | ENSBTAP00000053309 | ENSBTAP00000026148 | EDAR associated death domain. | Ectodysplasin A receptor. | 0.989 |
MAP3K20 | EDA | ENSBTAP00000058064 | ENSBTAP00000016649 | Uncharacterized protein. | Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. | 0.587 |