STRINGSTRING
EDA EDA EDAR EDAR EDA2R EDA2R EDARADD EDARADD MAP3K20 MAP3K20 MAP3K7 MAP3K7 MAPK10 MAPK10 MAPK9 MAPK9 MAPK8 MAPK8 TBX1 TBX1 DUSP16 DUSP16
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EDAEctodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. (261 aa)    
Predicted Functional Partners:
EDAR
Ectodysplasin A receptor.
     
 0.937
EDA2R
Ectodysplasin A2 receptor.
     
 0.934
EDARADD
EDAR associated death domain.
     
 0.618
MAP3K20
Uncharacterized protein.
    
 
 0.587
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...]
    
 
 0.587
MAPK10
Mitogen-activated protein kinase.
   
 
 0.570
MAPK9
Mitogen-activated protein kinase.
   
 
 0.570
MAPK8
Mitogen-activated protein kinase.
   
 
 0.570
TBX1
T-box transcription factor 1.
   
 
 0.437
DUSP16
Dual specificity phosphatase 16.
    
 
 0.420
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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