STRINGSTRING
ORMDL1 ORMDL1 SPTLC1 SPTLC1 SPTSSA SPTSSA SPTLC2 SPTLC2 SPTLC3 SPTLC3 ASNSD1 ASNSD1 SPTSSB SPTSSB PMS1 PMS1 ANKAR ANKAR FAM193B FAM193B MFSD13A MFSD13A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ORMDL1ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. (153 aa)    
Predicted Functional Partners:
SPTLC1
Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to [...]
   
 0.958
SPTSSA
Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI).
    
 0.920
SPTLC2
Serine palmitoyltransferase long chain base subunit 2.
    
 0.919
SPTLC3
Serine palmitoyltransferase long chain base subunit 3.
    
 0.905
ASNSD1
Asparagine synthetase domain-containing protein 1.
   
  
 0.754
SPTSSB
Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2- SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity).
     
 0.709
PMS1
PMS1 homolog 1, mismatch repair system component.
   
  
 0.698
ANKAR
Ankyrin and armadillo repeat containing.
    
 
 0.684
FAM193B
Protein FAM193B; Belongs to the FAM193 family.
      
 0.651
MFSD13A
Transmembrane protein 180.
      
 0.613
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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