STRINGSTRING
MAEA MAEA ARMC8 ARMC8 WDR26 WDR26 RMND5B RMND5B RANBP10 RANBP10 ZMYND19 ZMYND19 MKLN1 MKLN1 GID8 GID8 RMND5A RMND5A YPEL5 YPEL5 GID4 GID4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAEAE3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] (434 aa)    
Predicted Functional Partners:
ARMC8
Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
    
 0.971
WDR26
WD repeat domain 26.
    
 0.941
RMND5B
Required for meiotic nuclear division 5 homolog B (S. cerevisiae).
    
0.905
RANBP10
Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for [...]
    
 
 0.899
ZMYND19
Zinc finger MYND-type containing 19.
      
 0.897
MKLN1
MKLN1 protein.
    
 
 0.892
GID8
Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation; Belongs to the GID8 family.
  
 
 
 0.866
RMND5A
Required for meiotic nuclear division 5 homolog A.
    
0.863
YPEL5
Protein yippee-like 5; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity).
   
 
 0.777
GID4
GID complex subunit 4 homolog.
    
 
 0.773
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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