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PSPH PSPH PSAT1 PSAT1 SHMT2 SHMT2 SHMT1 SHMT1 AGXT AGXT CBS CBS PHGDH PHGDH SDS SDS SRR SRR SDSL SDSL THNSL2 THNSL2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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textmining
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protein homology
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PSPHPhosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family. (225 aa)    
Predicted Functional Partners:
PSAT1
Phosphoserine aminotransferase.
  
 
 0.999
SHMT2
Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...]
  
 0.997
SHMT1
Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine.
  
 0.996
AGXT
Serine--pyruvate aminotransferase.
   
 0.989
CBS
Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.966
PHGDH
D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 0.964
SDS
L-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family.
    
 0.938
SRR
Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
    
 0.927
SDSL
Serine dehydratase like.
    
 0.921
THNSL2
Threonine synthase like 2.
   
 0.852
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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