node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMELX | BPIFA2A | ENSBTAP00000016034 | ENSBTAP00000012052 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | 0.917 |
AMELX | CELA3B | ENSBTAP00000016034 | ENSBTAP00000017401 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Proproteinase E; May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum; Belongs to the peptidase S1 family. | 0.919 |
AMELX | GH1 | ENSBTAP00000016034 | ENSBTAP00000061093 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.917 |
AMELX | GUCY2D | ENSBTAP00000016034 | ENSBTAP00000011564 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Retinal guanylyl cyclase 1; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). | 0.917 |
AMELX | KIR2DL5A | ENSBTAP00000016034 | ENSBTAP00000057651 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | NK receptor KIR2DL1. | 0.917 |
AMELX | OPTC | ENSBTAP00000016034 | ENSBTAP00000018286 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. | 0.869 |
AMELX | PPM1B | ENSBTAP00000016034 | ENSBTAP00000043518 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF- alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). | 0.670 |
AMELX | PRPH2 | ENSBTAP00000016034 | ENSBTAP00000007836 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.919 |
AMELX | QPCT | ENSBTAP00000016034 | ENSBTAP00000018493 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity). | 0.629 |
BPIFA2A | AMELX | ENSBTAP00000012052 | ENSBTAP00000016034 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.917 |
BPIFA2A | CELA3B | ENSBTAP00000012052 | ENSBTAP00000017401 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Proproteinase E; May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum; Belongs to the peptidase S1 family. | 0.917 |
BPIFA2A | GH1 | ENSBTAP00000012052 | ENSBTAP00000061093 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.918 |
BPIFA2A | GUCY2D | ENSBTAP00000012052 | ENSBTAP00000011564 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Retinal guanylyl cyclase 1; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). | 0.917 |
BPIFA2A | KIR2DL5A | ENSBTAP00000012052 | ENSBTAP00000057651 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | NK receptor KIR2DL1. | 0.921 |
BPIFA2A | OPTC | ENSBTAP00000012052 | ENSBTAP00000018286 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils. May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. | 0.747 |
BPIFA2A | PPM1B | ENSBTAP00000012052 | ENSBTAP00000043518 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF- alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). | 0.600 |
BPIFA2A | PRPH2 | ENSBTAP00000012052 | ENSBTAP00000007836 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.907 |
BPIFA2A | QPCT | ENSBTAP00000012052 | ENSBTAP00000018493 | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity). | 0.511 |
CELA3B | AMELX | ENSBTAP00000017401 | ENSBTAP00000016034 | Proproteinase E; May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum; Belongs to the peptidase S1 family. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.919 |
CELA3B | BPIFA2A | ENSBTAP00000017401 | ENSBTAP00000012052 | Proproteinase E; May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum; Belongs to the peptidase S1 family. | Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | 0.917 |