STRINGSTRING
RSAD2 RSAD2 IFI44 IFI44 MX1 MX1 ISG15 ISG15 CMPK2 CMPK2 MX2 MX2 OASL OASL USP18 USP18 IFIH1 IFIH1 DDX58 DDX58 EIF2AK2 EIF2AK2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RSAD2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (363 aa)    
Predicted Functional Partners:
IFI44
Interferon induced protein 44.
   
  
 0.976
MX1
Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
   
  
 0.974
ISG15
Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated- killer (LAK) activi [...]
   
  
 0.973
CMPK2
Cytidine/uridine monophosphate kinase 2.
   
  
 0.972
MX2
Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV).
   
  
 0.966
OASL
2'-5'-oligoadenylate synthetase like.
   
  
 0.964
USP18
USP domain-containing protein; Belongs to the peptidase C19 family.
   
  
 0.963
IFIH1
Interferon induced with helicase C domain 1.
   
  
 0.945
DDX58
DExD/H-box helicase 58.
   
  
 0.943
EIF2AK2
Eukaryotic translation initiation factor 2-alpha kinase 2.
   
  
 0.942
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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