node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSBTAP00000063770 | NPB | ENSBTAP00000063770 | ENSBTAP00000018455 | Uncharacterized protein. | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | 0.636 |
ENSBTAP00000063770 | NPBWR1 | ENSBTAP00000063770 | ENSBTAP00000021510 | Uncharacterized protein. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.710 |
ENSBTAP00000063770 | NPBWR2 | ENSBTAP00000063770 | ENSBTAP00000054391 | Uncharacterized protein. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.710 |
ENSBTAP00000063770 | NPY | ENSBTAP00000063770 | ENSBTAP00000061725 | Uncharacterized protein. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. | 0.566 |
ENSBTAP00000063770 | PENK | ENSBTAP00000063770 | ENSBTAP00000066399 | Uncharacterized protein. | Met-enkephalin-Arg-Gly-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family. | 0.544 |
ENSBTAP00000063770 | PNOC | ENSBTAP00000063770 | ENSBTAP00000000695 | Uncharacterized protein. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.536 |
ENSBTAP00000063770 | POMC | ENSBTAP00000063770 | ENSBTAP00000010386 | Uncharacterized protein. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.547 |
ENSBTAP00000063770 | SST | ENSBTAP00000063770 | ENSBTAP00000023020 | Uncharacterized protein. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.527 |
GAMT | NPBWR1 | ENSBTAP00000005375 | ENSBTAP00000021510 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.595 |
GAMT | NPBWR2 | ENSBTAP00000005375 | ENSBTAP00000054391 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.426 |
GAMT | RCOR2 | ENSBTAP00000005375 | ENSBTAP00000010294 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. | REST corepressor 2. | 0.569 |
NPB | ENSBTAP00000063770 | ENSBTAP00000018455 | ENSBTAP00000063770 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Uncharacterized protein. | 0.636 |
NPB | NPBWR1 | ENSBTAP00000018455 | ENSBTAP00000021510 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.977 |
NPB | NPBWR2 | ENSBTAP00000018455 | ENSBTAP00000054391 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.982 |
NPB | NPY | ENSBTAP00000018455 | ENSBTAP00000061725 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. | 0.676 |
NPB | PENK | ENSBTAP00000018455 | ENSBTAP00000066399 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Met-enkephalin-Arg-Gly-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family. | 0.669 |
NPB | PNOC | ENSBTAP00000018455 | ENSBTAP00000000695 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. [Orphanin FQ2]: Has potent analgesic activity. Belongs to the opioid neuropeptide precursor family. | 0.564 |
NPB | POMC | ENSBTAP00000018455 | ENSBTAP00000010386 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Beta-endorphin]: Endogenous orexigenic opiate. | 0.616 |
NPB | SST | ENSBTAP00000018455 | ENSBTAP00000023020 | Neuropeptide B-29; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Belongs to the neuropeptide B/W family. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.672 |
NPBWR1 | ENSBTAP00000063770 | ENSBTAP00000021510 | ENSBTAP00000063770 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.710 |