node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEX3 | CPXM1 | ENSBTAP00000007916 | ENSBTAP00000039106 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity); Belongs to the BEX family. | Carboxypeptidase X, M14 family member 1. | 0.459 |
BEX3 | LAPTM4B | ENSBTAP00000007916 | ENSBTAP00000022559 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity); Belongs to the BEX family. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.478 |
BEX3 | SMIM24 | ENSBTAP00000007916 | ENSBTAP00000041958 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity); Belongs to the BEX family. | Small integral membrane protein 24. | 0.635 |
CPXM1 | BEX3 | ENSBTAP00000039106 | ENSBTAP00000007916 | Carboxypeptidase X, M14 family member 1. | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity); Belongs to the BEX family. | 0.459 |
CPXM1 | LAPTM4B | ENSBTAP00000039106 | ENSBTAP00000022559 | Carboxypeptidase X, M14 family member 1. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.506 |
CPXM1 | SMIM24 | ENSBTAP00000039106 | ENSBTAP00000041958 | Carboxypeptidase X, M14 family member 1. | Small integral membrane protein 24. | 0.709 |
GLB1L | LAPTM4B | ENSBTAP00000027467 | ENSBTAP00000022559 | Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.514 |
LAPTM4A | LAPTM4B | ENSBTAP00000027837 | ENSBTAP00000022559 | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | 0.931 |
LAPTM4A | LAPTM5 | ENSBTAP00000027837 | ENSBTAP00000007204 | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells. | 0.913 |
LAPTM4A | TP53I3 | ENSBTAP00000027837 | ENSBTAP00000004413 | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. | Tumor protein p53 inducible protein 3. | 0.564 |
LAPTM4B | BEX3 | ENSBTAP00000022559 | ENSBTAP00000007916 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity); Belongs to the BEX family. | 0.478 |
LAPTM4B | CPXM1 | ENSBTAP00000022559 | ENSBTAP00000039106 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Carboxypeptidase X, M14 family member 1. | 0.506 |
LAPTM4B | GLB1L | ENSBTAP00000022559 | ENSBTAP00000027467 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. | 0.514 |
LAPTM4B | LAPTM4A | ENSBTAP00000022559 | ENSBTAP00000027837 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. | 0.931 |
LAPTM4B | LAPTM5 | ENSBTAP00000022559 | ENSBTAP00000007204 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells. | 0.943 |
LAPTM4B | MPP7 | ENSBTAP00000022559 | ENSBTAP00000036176 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). | 0.482 |
LAPTM4B | NDST4 | ENSBTAP00000022559 | ENSBTAP00000056200 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | N-deacetylase and N-sulfotransferase 4. | 0.525 |
LAPTM4B | PLEKHF2 | ENSBTAP00000022559 | ENSBTAP00000026087 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Pleckstrin homology and FYVE domain containing 2. | 0.522 |
LAPTM4B | SMIM24 | ENSBTAP00000022559 | ENSBTAP00000041958 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Small integral membrane protein 24. | 0.677 |
LAPTM4B | TP53I3 | ENSBTAP00000022559 | ENSBTAP00000004413 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF- stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTO [...] | Tumor protein p53 inducible protein 3. | 0.480 |