node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC112446383 | PIAS1 | ENSBTAP00000073080 | ENSBTAP00000071691 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Protein inhibitor of activated STAT 1. | 0.798 |
LOC112446383 | PIAS4 | ENSBTAP00000073080 | ENSBTAP00000001000 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Protein inhibitor of activated STAT 4. | 0.686 |
LOC112446383 | RANBP2 | ENSBTAP00000073080 | ENSBTAP00000060769 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin- 1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore compl [...] | 0.994 |
LOC112446383 | RANGAP1 | ENSBTAP00000073080 | ENSBTAP00000012125 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Ran GTPase activating protein 1. | 0.977 |
LOC112446383 | SAE1 | ENSBTAP00000073080 | ENSBTAP00000062557 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.917 |
LOC112446383 | SENP1 | ENSBTAP00000073080 | ENSBTAP00000070053 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | SUMO specific peptidase 1. | 0.532 |
LOC112446383 | SUMO1 | ENSBTAP00000073080 | ENSBTAP00000066977 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.986 |
LOC112446383 | SUMO3 | ENSBTAP00000073080 | ENSBTAP00000023029 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.972 |
LOC112446383 | TP53 | ENSBTAP00000073080 | ENSBTAP00000001420 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.713 |
PIAS1 | LOC112446383 | ENSBTAP00000071691 | ENSBTAP00000073080 | Protein inhibitor of activated STAT 1. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.798 |
PIAS1 | RANBP2 | ENSBTAP00000071691 | ENSBTAP00000060769 | Protein inhibitor of activated STAT 1. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin- 1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore compl [...] | 0.780 |
PIAS1 | RANGAP1 | ENSBTAP00000071691 | ENSBTAP00000012125 | Protein inhibitor of activated STAT 1. | Ran GTPase activating protein 1. | 0.480 |
PIAS1 | SAE1 | ENSBTAP00000071691 | ENSBTAP00000062557 | Protein inhibitor of activated STAT 1. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.879 |
PIAS1 | SENP1 | ENSBTAP00000071691 | ENSBTAP00000070053 | Protein inhibitor of activated STAT 1. | SUMO specific peptidase 1. | 0.794 |
PIAS1 | SUMO1 | ENSBTAP00000071691 | ENSBTAP00000066977 | Protein inhibitor of activated STAT 1. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.942 |
PIAS1 | SUMO3 | ENSBTAP00000071691 | ENSBTAP00000023029 | Protein inhibitor of activated STAT 1. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.913 |
PIAS1 | TP53 | ENSBTAP00000071691 | ENSBTAP00000001420 | Protein inhibitor of activated STAT 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.691 |
PIAS1 | UBE2I | ENSBTAP00000071691 | ENSBTAP00000059318 | Protein inhibitor of activated STAT 1. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.862 |
PIAS4 | LOC112446383 | ENSBTAP00000001000 | ENSBTAP00000073080 | Protein inhibitor of activated STAT 4. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.686 |
PIAS4 | RANBP2 | ENSBTAP00000001000 | ENSBTAP00000060769 | Protein inhibitor of activated STAT 4. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin- 1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore compl [...] | 0.613 |