node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | ERBB2 | ENSBTAP00000070620 | ENSBTAP00000029056 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.998 |
EGFR | ERBB3 | ENSBTAP00000070620 | ENSBTAP00000013790 | Receptor protein-tyrosine kinase. | Erb-b2 receptor tyrosine kinase 3. | 0.992 |
EGFR | ERBB4 | ENSBTAP00000070620 | ENSBTAP00000071940 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.859 |
EGFR | GRB2 | ENSBTAP00000070620 | ENSBTAP00000006216 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 2. | 0.999 |
EGFR | GRB7 | ENSBTAP00000070620 | ENSBTAP00000023091 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...] | 0.798 |
EGFR | KIT | ENSBTAP00000070620 | ENSBTAP00000003498 | Receptor protein-tyrosine kinase. | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] | 0.446 |
EGFR | PDGFRB | ENSBTAP00000070620 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.977 |
EGFR | SRC | ENSBTAP00000070620 | ENSBTAP00000011767 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.992 |
ERBB2 | EGFR | ENSBTAP00000029056 | ENSBTAP00000070620 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.998 |
ERBB2 | ERBB3 | ENSBTAP00000029056 | ENSBTAP00000013790 | Receptor protein-tyrosine kinase. | Erb-b2 receptor tyrosine kinase 3. | 0.999 |
ERBB2 | ERBB4 | ENSBTAP00000029056 | ENSBTAP00000071940 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.994 |
ERBB2 | GRB2 | ENSBTAP00000029056 | ENSBTAP00000006216 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 2. | 0.991 |
ERBB2 | GRB7 | ENSBTAP00000029056 | ENSBTAP00000023091 | Receptor protein-tyrosine kinase. | Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...] | 0.964 |
ERBB2 | PDGFRB | ENSBTAP00000029056 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.670 |
ERBB2 | RND1 | ENSBTAP00000029056 | ENSBTAP00000024996 | Receptor protein-tyrosine kinase. | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | 0.604 |
ERBB2 | SRC | ENSBTAP00000029056 | ENSBTAP00000011767 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.970 |
ERBB3 | EGFR | ENSBTAP00000013790 | ENSBTAP00000070620 | Erb-b2 receptor tyrosine kinase 3. | Receptor protein-tyrosine kinase. | 0.992 |
ERBB3 | ERBB2 | ENSBTAP00000013790 | ENSBTAP00000029056 | Erb-b2 receptor tyrosine kinase 3. | Receptor protein-tyrosine kinase. | 0.999 |
ERBB3 | ERBB4 | ENSBTAP00000013790 | ENSBTAP00000071940 | Erb-b2 receptor tyrosine kinase 3. | Receptor protein-tyrosine kinase. | 0.985 |
ERBB3 | GRB2 | ENSBTAP00000013790 | ENSBTAP00000006216 | Erb-b2 receptor tyrosine kinase 3. | Growth factor receptor-bound protein 2. | 0.985 |