node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDO1 | CSAD | ENSBTAP00000023186 | ENSBTAP00000010305 | Cysteine dioxygenase type 1. | Cysteine sulfinic acid decarboxylase. | 0.979 |
CDO1 | CTH-2 | ENSBTAP00000023186 | ENSBTAP00000062349 | Cysteine dioxygenase type 1. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.976 |
CDO1 | GAD1 | ENSBTAP00000023186 | ENSBTAP00000009547 | Cysteine dioxygenase type 1. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.919 |
CDO1 | GAD2 | ENSBTAP00000023186 | ENSBTAP00000010598 | Cysteine dioxygenase type 1. | Glutamate decarboxylase 2. | 0.926 |
CDO1 | GADL1 | ENSBTAP00000023186 | ENSBTAP00000009385 | Cysteine dioxygenase type 1. | Acidic amino acid decarboxylase GADL1; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L- aspartate. Does not exhibit any decarboxylation activity toward glutamate. | 0.974 |
CDO1 | GOT1 | ENSBTAP00000023186 | ENSBTAP00000015873 | Cysteine dioxygenase type 1. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.955 |
CDO1 | GOT1L1 | ENSBTAP00000023186 | ENSBTAP00000021864 | Cysteine dioxygenase type 1. | Putative aspartate aminotransferase, cytoplasmic 2. | 0.912 |
CDO1 | GOT2 | ENSBTAP00000023186 | ENSBTAP00000009440 | Cysteine dioxygenase type 1. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.935 |
CDO1 | KYAT3 | ENSBTAP00000023186 | ENSBTAP00000000643 | Cysteine dioxygenase type 1. | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By sim [...] | 0.901 |
CDO1 | LOC529488 | ENSBTAP00000023186 | ENSBTAP00000064132 | Cysteine dioxygenase type 1. | Uncharacterized protein. | 0.919 |
CSAD | CDO1 | ENSBTAP00000010305 | ENSBTAP00000023186 | Cysteine sulfinic acid decarboxylase. | Cysteine dioxygenase type 1. | 0.979 |
CSAD | CTH-2 | ENSBTAP00000010305 | ENSBTAP00000062349 | Cysteine sulfinic acid decarboxylase. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.645 |
CSAD | GADL1 | ENSBTAP00000010305 | ENSBTAP00000009385 | Cysteine sulfinic acid decarboxylase. | Acidic amino acid decarboxylase GADL1; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L- aspartate. Does not exhibit any decarboxylation activity toward glutamate. | 0.901 |
CSAD | GOT1 | ENSBTAP00000010305 | ENSBTAP00000015873 | Cysteine sulfinic acid decarboxylase. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.853 |
CSAD | GOT1L1 | ENSBTAP00000010305 | ENSBTAP00000021864 | Cysteine sulfinic acid decarboxylase. | Putative aspartate aminotransferase, cytoplasmic 2. | 0.818 |
CSAD | GOT2 | ENSBTAP00000010305 | ENSBTAP00000009440 | Cysteine sulfinic acid decarboxylase. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.837 |
CTH-2 | CDO1 | ENSBTAP00000062349 | ENSBTAP00000023186 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Cysteine dioxygenase type 1. | 0.976 |
CTH-2 | CSAD | ENSBTAP00000062349 | ENSBTAP00000010305 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Cysteine sulfinic acid decarboxylase. | 0.645 |
CTH-2 | GADL1 | ENSBTAP00000062349 | ENSBTAP00000009385 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Acidic amino acid decarboxylase GADL1; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L- aspartate. Does not exhibit any decarboxylation activity toward glutamate. | 0.574 |
CTH-2 | GOT1 | ENSBTAP00000062349 | ENSBTAP00000015873 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.940 |