STRINGSTRING
OAZ1 OAZ1 AZIN1 AZIN1 ODC1 ODC1 RPL27 RPL27 EEF1G EEF1G RPL19 RPL19 F1MXF0_BOVIN F1MXF0_BOVIN ENSBTAP00000068688 ENSBTAP00000068688 ALAS1 ALAS1 AZIN2 AZIN2 POLR1B POLR1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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OAZ1Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome- interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular [...] (227 aa)    
Predicted Functional Partners:
AZIN1
Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 0.946
ODC1
Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 0.918
RPL27
60S ribosomal protein L27; Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).
   
  
 0.809
EEF1G
Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
   
  
 0.748
RPL19
60S ribosomal protein L19.
   
  
 0.738
F1MXF0_BOVIN
Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 
 0.710
ENSBTAP00000068688
Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 
 0.710
ALAS1
5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
      
 0.701
AZIN2
Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 
 0.687
POLR1B
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
      
 0.658
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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