STRINGSTRING
RFC2 RFC2 RAD17 RAD17 RFC3 RFC3 RFC5 RFC5 RFC4 RFC4 RFC1 RFC1 PCNA PCNA ATAD5 ATAD5 HUS1 HUS1 CHTF18 CHTF18 RAD9A RAD9A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
RFC2Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (352 aa)    
Predicted Functional Partners:
RAD17
RAD17 checkpoint clamp loader component.
    
 0.999
RFC3
Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
   
0.999
RFC5
Replication factor C subunit 5.
   
0.999
RFC4
Replication factor C subunit 4.
  
0.999
RFC1
Replication factor C subunit 1.
   
0.997
PCNA
Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...]
  
 0.994
ATAD5
ATPase family AAA domain containing 5.
   
 
 0.981
HUS1
Checkpoint protein; Belongs to the HUS1 family.
   
 0.976
CHTF18
Chromosome transmission fidelity factor 18.
   
 0.966
RAD9A
Cell cycle checkpoint control protein; Belongs to the rad9 family.
   
 0.950
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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