STRINGSTRING
WDR44 WDR44 TBC1D14 TBC1D14 RAB3GAP2 RAB3GAP2 RAB11FIP4 RAB11FIP4 SLC25A40 SLC25A40 RAB3GAP1 RAB3GAP1 VAPB VAPB RAB11FIP3 RAB11FIP3 LRRC17 LRRC17 VAPA VAPA BABAM1 BABAM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WDR44WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling. (912 aa)    
Predicted Functional Partners:
TBC1D14
TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
   
  
 0.693
RAB3GAP2
RAB3 GTPase activating non-catalytic protein subunit 2.
   
  
 0.691
RAB11FIP4
RAB11 family interacting protein 4.
      
 0.663
SLC25A40
Solute carrier family 25 member 40.
      
 0.651
RAB3GAP1
RAB3 GTPase activating protein catalytic subunit 1.
   
  
 0.630
VAPB
Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
   
 
 0.624
RAB11FIP3
RAB11 family interacting protein 3.
      
 0.600
LRRC17
Leucine rich repeat containing 17.
      
 0.598
VAPA
Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
   
 
 0.595
BABAM1
BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...]
      
 0.594
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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