node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIF1 | CD68 | ENSBTAP00000027388 | ENSBTAP00000000146 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | CD68 molecule. | 0.657 |
AIF1 | CSF1R | ENSBTAP00000027388 | ENSBTAP00000016977 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.622 |
AIF1 | CTSC | ENSBTAP00000027388 | ENSBTAP00000014735 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). | 0.614 |
AIF1 | ENSBTAP00000066257 | ENSBTAP00000027388 | ENSBTAP00000066257 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Uncharacterized protein. | 0.706 |
AIF1 | FCER1G | ENSBTAP00000027388 | ENSBTAP00000033956 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] | 0.803 |
AIF1 | GFAP | ENSBTAP00000027388 | ENSBTAP00000073843 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. | 0.682 |
AIF1 | ITGB2 | ENSBTAP00000027388 | ENSBTAP00000059292 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] | 0.745 |
AIF1 | PYCARD | ENSBTAP00000027388 | ENSBTAP00000027359 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8- dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase- 9, -2 and -3. Involved in macrophage pyroptosis, a cas [...] | 0.696 |
AIF1 | RNASE6 | ENSBTAP00000027388 | ENSBTAP00000011585 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram- negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity). | 0.694 |
AIF1 | TYROBP | ENSBTAP00000027388 | ENSBTAP00000070392 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.889 |
CD68 | AIF1 | ENSBTAP00000000146 | ENSBTAP00000027388 | CD68 molecule. | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | 0.657 |
CD68 | CSF1R | ENSBTAP00000000146 | ENSBTAP00000016977 | CD68 molecule. | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.868 |
CD68 | CTSC | ENSBTAP00000000146 | ENSBTAP00000014735 | CD68 molecule. | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). | 0.413 |
CD68 | FCER1G | ENSBTAP00000000146 | ENSBTAP00000033956 | CD68 molecule. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] | 0.582 |
CD68 | GFAP | ENSBTAP00000000146 | ENSBTAP00000073843 | CD68 molecule. | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. | 0.915 |
CD68 | ITGB2 | ENSBTAP00000000146 | ENSBTAP00000059292 | CD68 molecule. | Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] | 0.678 |
CD68 | TYROBP | ENSBTAP00000000146 | ENSBTAP00000070392 | CD68 molecule. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] | 0.818 |
CSF1R | AIF1 | ENSBTAP00000016977 | ENSBTAP00000027388 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Allograft inflammatory factor 1; May play a role in macrophage activation and function. | 0.622 |
CSF1R | CD68 | ENSBTAP00000016977 | ENSBTAP00000000146 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | CD68 molecule. | 0.868 |
CSF1R | FCER1G | ENSBTAP00000016977 | ENSBTAP00000033956 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] | 0.690 |