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NAP1L4 NAP1L4 TSSC4 TSSC4 OSBPL5 OSBPL5 CARS1 CARS1 LRWD1 LRWD1 PHLDA2 PHLDA2 MAGED2 MAGED2 NPM1-2 NPM1-2 NAP1L1 NAP1L1 CARS2 CARS2 SLC22A18 SLC22A18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAP1L4Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. (411 aa)    
Predicted Functional Partners:
TSSC4
Protein TSSC4; Belongs to the TSSC4 family.
      
 0.709
OSBPL5
Oxysterol-binding protein; Belongs to the OSBP family.
 
    
 0.685
CARS1
Cysteinyl-tRNA synthetase.
 
    
 0.645
LRWD1
Leucine rich repeats and WD repeat domain containing 1.
   
  
 0.642
PHLDA2
Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
      
 0.636
MAGED2
Melanoma antigen family D, 2.
   
 
 0.635
NPM1-2
Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...]
   
 
 0.628
NAP1L1
Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Belongs to the nucleosome assembly protein (NAP) family.
  
 
0.581
CARS2
Cysteine--tRNA ligase, mitochondrial.
 
    
 0.569
SLC22A18
Solute carrier family 22 member 18.
      
 0.566
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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