node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTRC | CUL1 | ENSBTAP00000009830 | ENSBTAP00000063991 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | Cullin 1; Belongs to the cullin family. | 0.991 |
BTRC | FBXW11 | ENSBTAP00000009830 | ENSBTAP00000066952 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | F-box and WD repeat domain containing 11. | 0.977 |
BTRC | LOC780968 | ENSBTAP00000009830 | ENSBTAP00000061525 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | RING-type domain-containing protein. | 0.981 |
BTRC | RBX1 | ENSBTAP00000009830 | ENSBTAP00000069463 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | RING-type domain-containing protein. | 0.907 |
BTRC | SKP1 | ENSBTAP00000009830 | ENSBTAP00000035184 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.984 |
BTRC | SKP2 | ENSBTAP00000009830 | ENSBTAP00000018036 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | SKP2 protein. | 0.939 |
CDK2 | CUL1 | ENSBTAP00000005252 | ENSBTAP00000063991 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Cullin 1; Belongs to the cullin family. | 0.988 |
CDK2 | LOC780968 | ENSBTAP00000005252 | ENSBTAP00000061525 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | RING-type domain-containing protein. | 0.954 |
CDK2 | RBX1 | ENSBTAP00000005252 | ENSBTAP00000069463 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | RING-type domain-containing protein. | 0.688 |
CDK2 | SKP1 | ENSBTAP00000005252 | ENSBTAP00000035184 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.991 |
CDK2 | SKP2 | ENSBTAP00000005252 | ENSBTAP00000018036 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | SKP2 protein. | 0.998 |
CUL1 | BTRC | ENSBTAP00000063991 | ENSBTAP00000009830 | Cullin 1; Belongs to the cullin family. | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.991 |
CUL1 | CDK2 | ENSBTAP00000063991 | ENSBTAP00000005252 | Cullin 1; Belongs to the cullin family. | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.988 |
CUL1 | CUL7 | ENSBTAP00000063991 | ENSBTAP00000053839 | Cullin 1; Belongs to the cullin family. | Cullin 7; Belongs to the cullin family. | 0.626 |
CUL1 | FBXL5 | ENSBTAP00000063991 | ENSBTAP00000028266 | Cullin 1; Belongs to the cullin family. | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). | 0.978 |
CUL1 | FBXW11 | ENSBTAP00000063991 | ENSBTAP00000066952 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 11. | 0.996 |
CUL1 | FBXW8 | ENSBTAP00000063991 | ENSBTAP00000047345 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 8. | 0.891 |
CUL1 | LOC780968 | ENSBTAP00000063991 | ENSBTAP00000061525 | Cullin 1; Belongs to the cullin family. | RING-type domain-containing protein. | 0.996 |
CUL1 | RBX1 | ENSBTAP00000063991 | ENSBTAP00000069463 | Cullin 1; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL1 | SKP1 | ENSBTAP00000063991 | ENSBTAP00000035184 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |