STRINGSTRING
HASPIN HASPIN CDCA8 CDCA8 BUB1 BUB1 INCENP INCENP SGO1 SGO1 CDK1 CDK1 HIST2H3D HIST2H3D LOC788077 LOC788077 LOC788077-2 LOC788077-2 LOC788077-3 LOC788077-3 LOC788077-4 LOC788077-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HASPINSerine/threonine-protein kinase haspin; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. (781 aa)    
Predicted Functional Partners:
CDCA8
Cell division cycle associated 8.
   
  
 0.896
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.887
INCENP
Inner centromere protein.
   
  
 0.870
SGO1
Shugoshin 1.
   
  
 0.828
CDK1
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...]
   
 
 0.765
HIST2H3D
Histone H3; Belongs to the histone H3 family.
   
 
 0.736
LOC788077
Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.736
LOC788077-2
Histone H3.
   
 
 0.736
LOC788077-3
Histone H3.
   
 
 0.736
LOC788077-4
Histone H3.
   
 
 0.736
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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