STRINGSTRING
DYDC2 DYDC2 NME5 NME5 PAGR1 PAGR1 DPY30 DPY30 CCSER2 CCSER2 DYDC1 DYDC1 GHITM GHITM WDR5 WDR5 JADE2 JADE2 LRWD1 LRWD1 ZCCHC24 ZCCHC24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DYDC2DPY30 domain-containing protein 2; Belongs to the dpy-30 family. (194 aa)    
Predicted Functional Partners:
NME5
NME/NM23 family member 5; Belongs to the NDK family.
   
 0.800
PAGR1
PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B [...]
     
 0.757
DPY30
Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity).
    
 0.743
CCSER2
Coiled-coil serine rich protein 2.
      
 0.738
DYDC1
DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. Belongs to the dpy-30 family.
  
 
0.697
GHITM
Growth hormone inducible transmembrane protein; Belongs to the BI1 family.
      
 0.695
WDR5
WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...]
   
 0.675
JADE2
Jade family PHD finger 2.
      
 0.633
LRWD1
Leucine rich repeats and WD repeat domain containing 1.
    
 
 0.631
ZCCHC24
Zinc finger CCHC-type containing 24.
      
 0.620
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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