STRINGSTRING
SELL SELL GLYCAM1 GLYCAM1 CD34 CD34 CD44 CD44 SELP SELP CD4 CD4 CCR7 CCR7 IFNG IFNG SELE SELE MADCAM1 MADCAM1 CD69 CD69
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (399 aa)    
Predicted Functional Partners:
GLYCAM1
Glycosylation-dependent cell adhesion molecule 1.
   
 
 0.998
CD34
CD34 molecule.
   
  
 0.952
CD44
CD44 antigen.
   
 
 0.943
SELP
P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family.
  
 
0.925
CD4
CD4 molecule.
   
 
 0.917
CCR7
C-C chemokine receptor type 7; Receptor for the MIP-3-beta chemokine; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.914
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.
   
  
 0.907
SELE
E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
  
 
0.897
MADCAM1
Mucosal vascular addressin cell adhesion molecule 1.
    
 
 0.897
CD69
Early activation molecule CD69.
   
  
 0.895
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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