STRINGSTRING
TATDN1 TATDN1 EIF3E EIF3E RNF139 RNF139 MRPL13 MRPL13 PFDN5 PFDN5 RHPN1 RHPN1 SAMD12 SAMD12 BCAS4 BCAS4 SNF8 SNF8 STAC2 STAC2 PKHD1L1 PKHD1L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TATDN1Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease. (297 aa)    
Predicted Functional Partners:
EIF3E
Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]
   
  
 0.857
RNF139
Ring finger protein 139.
   
  
 0.699
MRPL13
39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family.
  
  
 0.647
PFDN5
Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity).
   
  
 0.640
RHPN1
Rhophilin Rho GTPase binding protein 1.
      
 0.577
SAMD12
Sterile alpha motif domain containing 12.
      
 0.576
BCAS4
Uncharacterized protein.
      
 0.567
SNF8
Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.
      
 0.565
STAC2
SH3 and cysteine rich domain 2.
      
 0.564
PKHD1L1
PKHD1 like 1.
      
 0.553
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.