STRINGSTRING
LFNG LFNG DLL1 DLL1 DLL4 DLL4 JAG1 JAG1 MESP2 MESP2 NOTCH2 NOTCH2 HES7 HES7 DLL3 DLL3 POFUT1 POFUT1 HES5 HES5 TBX6 TBX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
LFNGBeta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. (400 aa)    
Predicted Functional Partners:
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
 
 0.723
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
 0.705
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
 0.702
MESP2
Mesoderm posterior bHLH transcription factor 2.
      
 0.699
NOTCH2
Notch receptor 2.
    
 
 0.680
HES7
Hes family bHLH transcription factor 7.
      
 0.676
DLL3
Delta like canonical Notch ligand 3.
    
 
 0.659
POFUT1
Protein O-fucosyltransferase 1a.
      
 0.657
HES5
Hes family bHLH transcription factor 5.
      
 0.618
TBX6
T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).
      
 0.614
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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