HIF3A protein (Homo sapiens) - STRING network view

STRING 9.05

HIF3A protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	HIF3A	hypoxia inducible factor 3, alpha subunit; Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4 [...] (669 aa)
		(Homo sapiens)
Predicted Functional Partners:
	EGLN1	egl nine homolog 1 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (426 aa)	•	•	•		0.978
	VHL	von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)	•	•	•		0.977
	EGLN3	egl nine homolog 3 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (239 aa)	•	•	•		0.975
	EGLN2	egl nine homolog 2 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (407 aa)	•	•	•		0.964
	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functi [...] (826 aa)	•	•	•	•	0.963
	CUL2	cullin 2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) [...] (745 aa)		•	•		0.927
	TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); SIII, also known as [...] (161 aa)		•	•		0.927
	TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as [...] (112 aa)		•	•		0.925
	ARNT	aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) recept [...] (789 aa)		•	•	•	0.924
	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)		•	•		0.923

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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