node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRTC2 | PPP4C | ENSOCUP00000013514 | ENSOCUP00000005480 | CREB regulated transcription coactivator 2. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.914 |
CRTC2 | PPP4R3A | ENSOCUP00000013514 | ENSOCUP00000015262 | CREB regulated transcription coactivator 2. | Protein phosphatase 4 regulatory subunit 3A. | 0.920 |
CRTC2 | PPP4R3B | ENSOCUP00000013514 | ENSOCUP00000005953 | CREB regulated transcription coactivator 2. | Protein phosphatase 4 regulatory subunit 3B. | 0.922 |
ENSOCUP00000027254 | PPP4C | ENSOCUP00000027254 | ENSOCUP00000005480 | Uncharacterized protein. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.949 |
ENSOCUP00000027254 | PPP4R1 | ENSOCUP00000027254 | ENSOCUP00000029628 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 1. | 0.584 |
ENSOCUP00000027254 | PPP4R3A | ENSOCUP00000027254 | ENSOCUP00000015262 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 3A. | 0.825 |
ENSOCUP00000027254 | PPP4R3B | ENSOCUP00000027254 | ENSOCUP00000005953 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 3B. | 0.814 |
ENSOCUP00000027254 | PTPA | ENSOCUP00000027254 | ENSOCUP00000044909 | Uncharacterized protein. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] | 0.806 |
G1TK57_RABIT | PPP4C | ENSOCUP00000017340 | ENSOCUP00000005480 | Uncharacterized protein. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.949 |
G1TK57_RABIT | PPP4R1 | ENSOCUP00000017340 | ENSOCUP00000029628 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 1. | 0.584 |
G1TK57_RABIT | PPP4R3A | ENSOCUP00000017340 | ENSOCUP00000015262 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 3A. | 0.825 |
G1TK57_RABIT | PPP4R3B | ENSOCUP00000017340 | ENSOCUP00000005953 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 3B. | 0.814 |
G1TK57_RABIT | PTPA | ENSOCUP00000017340 | ENSOCUP00000044909 | Uncharacterized protein. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] | 0.806 |
G1U060_RABIT | PPP4C | ENSOCUP00000022738 | ENSOCUP00000005480 | Uncharacterized protein. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.901 |
G1U060_RABIT | PPP4R1 | ENSOCUP00000022738 | ENSOCUP00000029628 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 1. | 0.400 |
G1U060_RABIT | PTPA | ENSOCUP00000022738 | ENSOCUP00000044909 | Uncharacterized protein. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] | 0.638 |
IGBP1 | PPP4C | ENSOCUP00000009858 | ENSOCUP00000005480 | Uncharacterized protein. | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | 0.910 |
IGBP1 | PPP4R1 | ENSOCUP00000009858 | ENSOCUP00000029628 | Uncharacterized protein. | Protein phosphatase 4 regulatory subunit 1. | 0.400 |
IGBP1 | PTPA | ENSOCUP00000009858 | ENSOCUP00000044909 | Uncharacterized protein. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] | 0.770 |
PPP4C | CRTC2 | ENSOCUP00000005480 | ENSOCUP00000013514 | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] | CREB regulated transcription coactivator 2. | 0.914 |