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PPP4C PPP4C PPP4R3A PPP4R3A PPP4R3B PPP4R3B PPP4R2 PPP4R2 PTPA PTPA G1TK57_RABIT G1TK57_RABIT ENSOCUP00000027254 ENSOCUP00000027254 PPP4R1 PPP4R1 CRTC2 CRTC2 IGBP1 IGBP1 G1U060_RABIT G1U060_RABIT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPP4CSerine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] (307 aa)    
Predicted Functional Partners:
PPP4R3A
Protein phosphatase 4 regulatory subunit 3A.
   
 0.997
PPP4R3B
Protein phosphatase 4 regulatory subunit 3B.
   
 0.988
PPP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2.
   
 0.985
PTPA
Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]
   
 0.965
G1TK57_RABIT
Uncharacterized protein.
   
 0.949
ENSOCUP00000027254
Uncharacterized protein.
   
 0.949
PPP4R1
Protein phosphatase 4 regulatory subunit 1.
   
 0.933
CRTC2
CREB regulated transcription coactivator 2.
   
 0.914
IGBP1
Uncharacterized protein.
   
 
 0.910
G1U060_RABIT
Uncharacterized protein.
    
 
 0.901
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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