STRINGSTRING
PAK2 PAK2 CDC42-2 CDC42-2 ARHGEF6 ARHGEF6 NCK1 NCK1 RAC1 RAC1 NCK2 NCK2 PAK1 PAK1 CDC42 CDC42 LIMK1 LIMK1 LIMK2 LIMK2 ITSN2 ITSN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
PAK2Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa)    
Predicted Functional Partners:
CDC42-2
Uncharacterized protein.
   
 0.995
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
   
 0.993
NCK1
Cytoplasmic protein.
   
 0.975
RAC1
Rac family small GTPase 1.
   
 0.975
NCK2
Cytoplasmic protein.
    
 0.973
PAK1
Non-specific serine/threonine protein kinase.
  
 
0.965
CDC42
Uncharacterized protein.
   
 0.960
LIMK1
LIM domain kinase 1.
    
0.959
LIMK2
LIM domain kinase 2.
    
0.952
ITSN2
Intersectin 2.
    
 0.950
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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