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HNRNPK HNRNPK HNRNPU HNRNPU HNRNPA1 HNRNPA1 HNRNPL HNRNPL HNRNPA2B1 HNRNPA2B1 HNRNPA2B1-2 HNRNPA2B1-2 HNRNPF HNRNPF PCBP1 PCBP1 SRSF3 SRSF3 HNRNPD HNRNPD HNRNPC HNRNPC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
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[Homology]
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HNRNPKHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)    
Predicted Functional Partners:
HNRNPU
Heterogeneous nuclear ribonucleoprotein U.
   
 0.954
HNRNPA1
Uncharacterized protein.
   
 0.932
HNRNPL
Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.927
HNRNPA2B1
Heterogeneous nuclear ribonucleoprotein A2/B1.
   
 0.876
HNRNPA2B1-2
Heterogeneous nuclear ribonucleoprotein A2/B1.
   
 0.876
HNRNPF
Uncharacterized protein.
   
 0.870
PCBP1
Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
   
0.851
SRSF3
Serine and arginine rich splicing factor 3.
   
 0.847
HNRNPD
Heterogeneous nuclear ribonucleoprotein D.
   
 0.840
HNRNPC
Heterogeneous nuclear ribonucleoprotein C; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilit [...]
   
 0.833
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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