version_number_image
 
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BACE1
Beta-secretase 1 precursor (EC 3.4.23.46) (Beta-site APP cleaving enzyme 1) (Beta-site amyloid precursor protein cleaving enzyme 1) (Membrane-associated aspartic protease 2) (Memapsin-2) (Aspartyl protease 2) (Asp 2) (ASP2); Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (501 aa)
(Homo sapiens)
Predicted Functional Partners:
PSEN1
Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains- Presenilin-1 NTF subunit; Presenili [...] (467 aa)
      0.994
APP
Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral va [...] (770 aa)
     0.992
NCSTN
Nicastrin precursor; Essential subunit of the gamma-secretase complex, an endoprotease complex [...] (709 aa)
      0.989
RTN3
Reticulon-3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII); May be inv [...] (1034 aa)
       0.980
GGA1
ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-bindin [...] (656 aa)
       0.954
LRP1
Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin recep [...] (4544 aa)
      0.946
FURIN
Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasi [...] (794 aa)
      0.911
PLSCR1
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Eryth [...] (318 aa)
      0.901
APBB1
Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein); May modulate the in [...] (719 aa)
       0.876
SORL1
Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A r [...] (2214 aa)
       0.850
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes         or: network depth