aceK protein (Polaromonas naphthalenivorans)

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	aceK	Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) (623 aa)
		(Polaromonas naphthalenivorans)
Predicted Functional Partners:
	Pnap_2855	Isocitrate lyase (439 aa)	•		•	•	0.808
	Pnap_1930	isocitrate dehydrogenase, NADP-dependent (417 aa)	•	•		•	0.688
	Pnap_0458	Acetyl-CoA acetyltransferases (393 aa)	•				0.640
	Pnap_0456	Carbonate dehydratase (219 aa)	•				0.634
	Pnap_0459	Acyl-CoA dehydrogenase domain protein (376 aa)	•				0.530
	Pnap_0455	acyl-CoA dehydrogenase domain protein (393 aa)	•				0.511
	Pnap_1475	Putative uncharacterized protein (263 aa)		•			0.487
	Pnap_1153	protein of unknown function DUF214 (857 aa)	•	•			0.486
	Pnap_0460	Rhodanese domain protein (138 aa)	•				0.461
	Pnap_4696	Beta-lactamase domain protein (400 aa)	•				0.458

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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