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  Lef1 protein (Rattus norvegicus) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Lef1
Lymphoid enhancer-binding factor 1 (LEF-1); Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity) (397 aa)
(Rattus norvegicus)
Predicted Functional Partners:
Ctnnb1
Catenin beta-1 (Beta-catenin); Involved in the regulation of cell adhesion and in signal transd [...] (781 aa)
     0.998
Wnt2
Wingless-type MMTV integration site family member 2; Ligand for members of the frizzled family [...] (360 aa)
       0.945
Jup
Junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are ar [...] (745 aa)
     0.941
Dsg4
Desmoglein-4 precursor; Component of intercellular desmosome junctions. Involved in the interac [...] (1040 aa)
       0.903
Ruvbl1
RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-inte [...] (456 aa)
      0.865
Smad4
Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Smad4); Com [...] (551 aa)
     0.828
Axin1
Axin-1 (Axis inhibition protein 1) (rAxin); Controls dorsoventral patterning via two opposing e [...] (863 aa)
       0.815
Crebbp
CREB binding protein (2444 aa)
      0.812
Ctbp1
C-terminal-binding protein 1 (EC 1.1.1.-) (CtBP1) (C-terminal-binding protein 3) (CtBP3) (50 kD [...] (441 aa)
       0.807
ENSRNOG00000005872
annotation not available (419 aa)
     0.803
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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