WNT1 protein (Homo sapiens) - STRING interaction network

WNT1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	WNT1	Proto-oncogene protein Wnt-1 precursor; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters (370 aa)
		(Homo sapiens)
Predicted Functional Partners:
	LRP6	Low-density lipoprotein receptor-related protein 6 precursor; Essential for the Wnt/beta cateni [...] (1613 aa)	•	•	•	0.999
	SFRP1	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (S [...] (314 aa)	•	•	•	0.998
	CTNNB1	Catenin beta-1 (Beta-catenin); Involved in the regulation of cell adhesion and in signal transd [...] (781 aa)		•	•	0.996
	DVL1	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1); May play a [...] (695 aa)		•	•	0.996
	FZD8	Frizzled-8 precursor (Fz-8) (hFz8); Receptor for Wnt proteins. Most of frizzled receptors are c [...] (694 aa)	•	•	•	0.994
	AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin); Controls dorsoventral patterning via two opposing e [...] (911 aa)		•	•	0.994
	WIF1	Wnt inhibitory factor 1 precursor (WIF-1); Binds to WNT proteins and inhibits their activities. [...] (379 aa)		•	•	0.991
	GSK3B	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta); Participates in the Wnt signaling [...] (433 aa)		•	•	0.986
	SMAD4	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion ta [...] (552 aa)		•	•	0.984
	LEF1	Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1 [...] (399 aa)		•	•	0.979

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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