ZAR1L protein (human) - STRING interaction network

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Score

ZAR1L

ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family. (321 aa)

Predicted Functional Partners:

ZNF879

0.584

BTG4

0.496

WEE2

0.446

NPM2

0.442

ZNF596

0.431

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTG4	WEE2	ENSP00000348300	ENSP00000380675	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear format [...]	0.577
BTG4	ZAR1L	ENSP00000348300	ENSP00000437289	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	0.496
BTG4	ZNF596	ENSP00000348300	ENSP00000381613	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.467
NPM2	ZAR1L	ENSP00000381032	ENSP00000437289	Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Belongs to the nucleoplasmin family.	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	0.442
WEE2	BTG4	ENSP00000380675	ENSP00000348300	Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear format [...]	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	0.577
WEE2	ZAR1L	ENSP00000380675	ENSP00000437289	Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear format [...]	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	0.446
ZAR1L	BTG4	ENSP00000437289	ENSP00000348300	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	0.496
ZAR1L	NPM2	ENSP00000437289	ENSP00000381032	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Belongs to the nucleoplasmin family.	0.442
ZAR1L	WEE2	ENSP00000437289	ENSP00000380675	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear format [...]	0.446
ZAR1L	ZNF596	ENSP00000437289	ENSP00000381613	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	Zinc finger protein 596; May be involved in transcriptional regulation.	0.431
ZAR1L	ZNF879	ENSP00000437289	ENSP00000414887	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	Zinc finger protein 879; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	0.584
ZNF596	BTG4	ENSP00000381613	ENSP00000348300	Zinc finger protein 596; May be involved in transcriptional regulation.	Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.	0.467
ZNF596	ZAR1L	ENSP00000381613	ENSP00000437289	Zinc finger protein 596; May be involved in transcriptional regulation.	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	0.431
ZNF879	ZAR1L	ENSP00000414887	ENSP00000437289	Zinc finger protein 879; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.	ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.	0.584