mitogen activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4) (By similarity) (427 aa)

Jun oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'- [...] (334 aa)

mitogen activated protein kinase kinase 7; Stress activated, dual specificity kinase that activ [...] (535 aa)

mitogen-activated protein kinase 8 interacting protein 3; The JNK-interacting protein (JIP) gro [...] (1337 aa)

Bcl-associated death promoter; Promotes cell death. Successfully competes for the binding to Bc [...] (204 aa)

catenin (cadherin associated protein), beta 1; Involved in the regulation of cell adhesion and [...] (781 aa)

interleukin 1 beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)

activating transcription factor 2; Transcriptional activator, probably constitutive, which bind [...] (487 aa)

mitogen-activated protein kinase kinase kinase 7 interacting protein 1; May be an important sig [...] (502 aa)

BCL2-like 11 (apoptosis facilitator); Induces apoptosis. The isoforms vary in cytotoxicity with [...] (196 aa)

mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Regulates the IL1-media [...] (693 aa)