aceK protein (Pseudomonas aeruginosa PA7) - STRING interaction network

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	aceK	Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) (577 aa)
		(Pseudomonas aeruginosa PA7)
Predicted Functional Partners:
	icd	isocitrate dehydrogenase, NADP-dependent (418 aa)	•	•	•	0.684
	PA1377	Putative uncharacterized protein (177 aa)	•			0.640
	PSPA7_3749	Fe-S-cluster domain (134 aa)		•		0.565
	PA4676	probable carbonic anhydrase (215 aa)	•			0.536
	PA1412	Putative uncharacterized protein (397 aa)		•		0.441
	PA2154	Putative uncharacterized protein (331 aa)		•		0.438
	idh	Isocitrate dehydrogenase, NADP-dependent (741 aa)	•			0.427
	dgt	Deoxyguanosinetriphosphate triphosphohydrolase (DGTPase) (498 aa)		•		0.416

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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